{"created":"2023-05-15T16:44:27.906450+00:00","id":20157,"links":{},"metadata":{"_buckets":{"deposit":"ecf57fc0-e372-4745-a35f-4e04b5c7482c"},"_deposit":{"created_by":2,"id":"20157","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20157"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020157","sets":["29:30:1713167819629:1393"]},"author_link":["85020","85019","85017","85022","85021","85018","85023"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"43","bibliographicPageStart":"38","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To study the process of cell death in cervical squamous cell carcinoma (SCC) after radiation, an ultrastructural and immunohistochemical study was performed. Paraffinembedded tissue blocks of biopsy samples pre- and postradiation stage III SCC (n = 15) were collected. Irradiation caused varying ultrastructural changes including nuclear and cytoplasmic disorganization suggesting cell necrosis. Immunohistochemically, the pre-radiation specimens showed no positive reaction for tumor necrosis factor-alpha (TNF- ﾎｱ),tumor necrosis factor-receptor(TNF-ﾎｳ)or Fas. C-fos, p 53 and bcl-2 showed positive reactions in only a few nonirradiated specimens. All of the irradiated specimens showed a positive reaction for TNF-ﾎｱ,and variable positive reactions  were observed for TNF-ﾎｳ,Fas, p 53, c-fos and bcl-2. These results suggest that TNF-ﾎｱ,TNF-ﾎｳ,and c-fos are responsible for radiation induced cell death in cervical SCC.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1998, 43(1-2), p.38-43","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00038-P00043"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Atari, Eio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toda, Takayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muktafisadi, Al"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Egawa, Haruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moromizat, Hidehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mamadi, Touye"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyuna, Masaya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta43_01_07_t.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta43_01_07_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20157/files/acta43_01_07_t.pdf"},"version_id":"b3c9b8bc-fd81-4c80-9d35-880e2e40e105"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cervical squamous cell carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"cell death","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-alpha","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-receptor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiation Induced Cell Death in Cervical Squamous Cell Carcinoma : An Immunohistochemical and Ultrastructural Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation Induced Cell Death in Cervical Squamous Cell Carcinoma : An Immunohistochemical and Ultrastructural Study"}]},"item_type_id":"3","owner":"2","path":["1393"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20157","relation_version_is_last":true,"title":["Radiation Induced Cell Death in Cervical Squamous Cell Carcinoma : An Immunohistochemical and Ultrastructural Study"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:05:19.805360+00:00"}