{"created":"2023-05-15T16:44:28.455907+00:00","id":20170,"links":{},"metadata":{"_buckets":{"deposit":"bd2621b9-4938-4a2a-b5a6-3e2f1abd8acc"},"_deposit":{"created_by":2,"id":"20170","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20170"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020170","sets":["29:30:1713167819629:1394"]},"author_link":["85081","85079","85082","85078","85080"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-12-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"56","bibliographicPageStart":"48","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We used the quantitative receptor autoradiographic method with a radioligand of [ 125I ]lysergic acid diethylamide ([125I]LSD) to quantitate platelet serotonin (5-HT)2A receptors in affective disorders. Specific binding of [125I]LSD to human platelet pellet sections was saturable, and of high affinity and single. Both ketanserin and spiperone, 5-HT2A selective ligands, inhibited [125I]LSD binding to human platelet pellets with high potency (IC50 values of 0.15 and 0.19 nM, respectively), whereas 5-HT and paroxetine, selective 5- HT re-uptake inhibitors, inhibited binding with a very low potency. These data confirmed that binding sites of human platelet pellets specifically labelled by [125I] LSD were 5-HT2A receptors. The number of 5-HT2A receptors (Bmax of [ 125I] LSD binding) of human platelets obtained from drug-free depressed patients was significantly higher than those of healthy volunteers. There were no statistical differences in the number of 5-HT2A receptors between depressed patients with and without suicidal behaviors. The increased number in platelet 5-HT2A receptotrs may indicate a hyperfunction of the central 5-HT2A receptors. The method with human platelets pellet sections we used is simple and sensitive for investigating platelet 5-HT2A receptors, a diagnostic and therapeutic marker in depressive disorders, in the clinical research.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1998, 43(3-4), p.48-56","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00048-P00056"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsujimura, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asou, Tadafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Himeno, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Yoshibumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta43_03_07_t.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta43_03_07_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20170/files/acta43_03_07_t.pdf"},"version_id":"d0f081ad-0028-45a8-8891-cda98c36972f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"5-HT2A receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"platelet","subitem_subject_scheme":"Other"},{"subitem_subject":"affective disorders","subitem_subject_scheme":"Other"},{"subitem_subject":"quantitative receptor autoradiography","subitem_subject_scheme":"Other"},{"subitem_subject":"[ 1 25IL] SD","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Platelet Serotonin (5-HT)2A Receptor Binding Sites in Affective Disorders: A Quantitative Receptor Autoradiographic Study with [ 125I ] Lysergic Acid Diethylamide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Platelet Serotonin (5-HT)2A Receptor Binding Sites in Affective Disorders: A Quantitative Receptor Autoradiographic Study with [ 125I ] Lysergic Acid Diethylamide"}]},"item_type_id":"3","owner":"2","path":["1394"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20170","relation_version_is_last":true,"title":["Platelet Serotonin (5-HT)2A Receptor Binding Sites in Affective Disorders: A Quantitative Receptor Autoradiographic Study with [ 125I ] Lysergic Acid Diethylamide"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:04:50.001919+00:00"}