@article{oai:nagasaki-u.repo.nii.ac.jp:00020180,
 author = {Yui, Katsuyuki},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {Rearrangement of the antigen-specific lymphocyte receptor genes generates repertoire of T and B cells that can attack any emerging pathogens as well as host tissue itself. This horror autotoxicus has to be removed by mechanisms collectively called self-tolerance. Recent advances in immunological science revealed that there are multiple mechanisms of tolerance both in central and peripheral organs. However, it has become more and more apparent that cellular mechanisms that induce tolerance (inactivation) and activation of lymphocytes are quite similar. Possible mechanisms by which immune system distinguishes self-structure from pathogens will be discussed., Acta medica Nagasakiensia. 1999, 44(1-2), p.1-10},
 pages = {1--10},
 title = {Immunological Tolerance, Autoimmunity and Host Defense},
 volume = {44},
 year = {1999}
}