@article{oai:nagasaki-u.repo.nii.ac.jp:00020197,
 author = {Gu, Weili and Yamaguchi, Junzo and Hashimoto, Toshiaki and Yamamoto, Takao and Nakayama, Eiichi and Kanematsu, Takashi},
 issue = {3-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {In orthotopic liver transplantation from Lewis (LEW) into Wistar Furth (WF) rats, a transient acute rejection response is usually followed by spontaneous tolerance of the graft. In this study, we investigated the alloimmunostimulatory ability of the graft and recipient spleen after liver transplantation, and studied the kinetic response of the recipient to the donor antigen. Alloimmunogenicity of the liver graft and recipient spleen, and kinetic response of the recipient were investigated in in vivo system. Alloimmunostimulatory ability of the liver graft disappeared by day 3 after transplantation. Alloimmunostimulatory capacity of recipient spleen was maximum 12 hours after grafting and rapidly disappeared thereafter. Challenge with normal LEW lymphocytes into recipient WF rats at 14, 28, 56 days after liver transplantation induced a progressive increase in rejection response. Our results suggest that rapid loss of graft immunogenicity and transient hyporesponsiveness to the donor antigen occur after grafting in our model., Acta medica Nagasakiensia. 1999, 44(3-4), p.31-38},
 pages = {31--38},
 title = {Rapid Loss of Graft Immunogenicity and Transient Hyporesponsiveness to The Donor Antigen After Rat Liver Transplantation},
 volume = {44},
 year = {1999}
}