@article{oai:nagasaki-u.repo.nii.ac.jp:00020208,
 author = {Matsunaga, Yoshitaka and Bae, Sangjae and Akikawa, Tomio and Kadota, Jun-Ichi and Katayama, Ichiro},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {We investigated the clinical efficacy of low-dose and long-term 14-member macrolide therapy for 33 patients with Palomoplantar Pustulosis (PPP) most of whom showed a poor clinical response to topical corticosteroid and/or photo chemotherapy. After 4-12 weeks treatment with oral erythromycin (EM; 600mg/day) or clarithromycin (CAM ; 200 mg/day) in combination with previously used corticosteroid ointment, clinical evaluation was made on the basis of clinical score. Results are as follows: marked improvement ; 19 patients (57.6%), moderate improvement ; 7 patients, no clinical response ; 7 patients. There was no serious side effect during the observation period. In vitro studies suggest that CAM, a 14-member macrolide, significantly down-regulated IL-8 production by keratinocytes stimulated with combination of IFNﾎｳ and TNFﾎｱ  or staphylococcal-superantigen(SEB)and IFNﾎｳ  both at protein and mRNA levels. We would like to propose that low-dose and long-term 14-member macrolide therapy is effective and an alternate therapy for PPP with poor response to ordinal dermatological therapy of which mechanism is presumable inhibition of neutrophil chemotaxisis by inhibiting IL-8 production by keratinocytes., Acta medica Nagasakiensia. 2000, 45(1-2), p.25-31},
 pages = {25--31},
 title = {Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis},
 volume = {45},
 year = {2000}
}