{"created":"2023-05-15T16:44:30.635271+00:00","id":20208,"links":{},"metadata":{"_buckets":{"deposit":"e8fdfcb6-65b4-4904-bee7-7623eaecd329"},"_deposit":{"created_by":2,"id":"20208","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20208"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020208","sets":["29:30:1713167819629:1397"]},"author_link":["85357","85356","85355","85353","85354"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-06-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"31","bibliographicPageStart":"25","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the clinical efficacy of low-dose and long-term 14-member macrolide therapy for 33 patients with Palomoplantar Pustulosis (PPP) most of whom showed a poor clinical response to topical corticosteroid and/or photo chemotherapy. After 4-12 weeks treatment with oral erythromycin (EM; 600mg/day) or clarithromycin (CAM ; 200 mg/day) in combination with previously used corticosteroid ointment, clinical evaluation was made on the basis of clinical score. Results are as follows: marked improvement ; 19 patients (57.6%), moderate improvement ; 7 patients, no clinical response ; 7 patients. There was no serious side effect during the observation period. In vitro studies suggest that CAM, a 14-member macrolide, significantly down-regulated IL-8 production by keratinocytes stimulated with combination of IFNﾎｳ and TNFﾎｱ  or staphylococcal-superantigen(SEB)and IFNﾎｳ  both at protein and mRNA levels. We would like to propose that low-dose and long-term 14-member macrolide therapy is effective and an alternate therapy for PPP with poor response to ordinal dermatological therapy of which mechanism is presumable inhibition of neutrophil chemotaxisis by inhibiting IL-8 production by keratinocytes.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2000, 45(1-2), p.25-31","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00025-P00031"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsunaga, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bae, Sangjae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akikawa, Tomio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Jun-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta45_01_04_t.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta45_01_04_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20208/files/acta45_01_04_t.pdf"},"version_id":"e9ad5200-a18f-43b8-b8cc-176899bedfba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"palmoplantar pustulosis","subitem_subject_scheme":"Other"},{"subitem_subject":"macrolide","subitem_subject_scheme":"Other"},{"subitem_subject":"keratinocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-8","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis"}]},"item_type_id":"3","owner":"2","path":["1397"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20208","relation_version_is_last":true,"title":["Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:03:53.617572+00:00"}