@article{oai:nagasaki-u.repo.nii.ac.jp:00020212,
 author = {Nakagoe, Tohru and Sawai, Terumitsu and Tsuji, Takashi and Jibiki, Masaaki and Ohbatake, Masayuki and Nakashima, Atsushi and Yamaguchi, Hiroyuki and Kurosaki, Nobuko and Yasutake, Toru and Ayabe, Hiroyoshi and Miyashita, Hiroko and Arisawa, Kokichi},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {Aims: We examined the preoperative serum levels of sialyl Lewisa (CA19-9) and carcinoembryonic antigen (CEA) in 262 colorectal cancer patients, in order to clarify whether or not the prognostic value of CA19-9 after curative surgery is superior to that of CEA. Patients and Methods: The patients were divided into two groups: low or high antigen groups (higher or lower than a selected diagnostic-based cut-off value). For evaluation of the prognostic value of CA19-9 and CEA, the disease-free interval was studied. Results: The disease-free interval of patients with a high serum levels of CA19-9 or CEA was significantly shorter than for those patients with a low serum level of the particular antigen (P<0.0001 and P=0.0009, respectively). The disease-free interval of patients with stage I/II tumors who had a high CA19-9 level was significantly shorter than in those patients with stage I/II tumors with low CA19-9 levels (P=0.0020). In contrast, the disease-free interval of patients with stage I/II tumors who had a low or high CEA level did not differ. Cox s regression analysis revealed that a high serum level of CA19-9 or CEA was an independent predictor for short disease-free interval after curative surgery, separate from stage (Hazard ratio=2.65 or 1.68, respectively, versus a low serum level of each respective antigen) . Conclusions: These data suggest that the preoperative serum level of CA19-9 was a stronger prognostic factor after curative surgery than CEA. Furthermore, in contrast to CEA, CA19-9 provides more prognostic information than that obtained by conventional staging methods in patients with stage I/II tumors., Acta medica Nagasakiensia. 2000, 45(1-2), p.47-50},
 pages = {47--50},
 title = {Prognostic Value of Circulating CA 19-9 in Colorectal Cancer Patients},
 volume = {45},
 year = {2000}
}