@article{oai:nagasaki-u.repo.nii.ac.jp:00020213,
 author = {Nakagoe, Tohru and Nanashima, Atsushi and Sawai, Terumitsu and Tsuji, Takashi and Ohbatake, Masayuki and Jibiki, Masaaki and Yamaguchi, Hiroyuki and Kurosaki, Nobuko and Yasutaka, Toru and Ayabe, Hiroyoshi and Miyashita, Hiroko and Arisawa, Kokichi},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {Background- Two distinct morphologic types of colorectal cancer have been described in recent studies: polypoid growth type (PG-type) and nonpolypoid growth type (NPG-type). Materials and Methods- We investigated possible biological and clinical differences between 37 PG-type and 156 NPGtype cancers using both univariate and multivariate analyses (logistic and Cox regression models). Results- Unlike NPG-type cancers, PG-type cancers had a high proportion of well-differentiated adenocarcinoma cells, a high likelihood of being early colorectal cancers (carcinoma in situ and cancer invades submucosa), and a low frequency of lymph node metastasis. On average, such PG-type cancers also carried a better prognosis than NPG-type cancers (P=0.01). In particular, PG-type cancer patients with stage IV tumors had a better prognosis than NPG-type cancer patients (P=0.02). In fact, after performing a Cox regression analysis, we found that colorectal cancer growth type is an independent prognostic variable, separate from histologic type or stage. Conclusions- PG-type colorectal cancer is less aggressive and has a favorable prognosis compared to NPG-type cancer., Acta medica Nagasakiensia. 2000, 45(1-2), p.51-59},
 pages = {51--59},
 title = {Biological Differences Between. Polypoid and Nonpolypoid Growth Types of Colorectal Cancer},
 volume = {45},
 year = {2000}
}