@article{oai:nagasaki-u.repo.nii.ac.jp:00020219,
 author = {Nakata, Keisuke and Nakao, Kazuhiko and Morikawa, Takashi and Inokuchi, Kaoru and Hamasaki, Keisuke and Tsuruta, Shotaro and Kato, Yuji and Yatsuhashi, Hiroshi and Kusumoto, Yukio and Ishii, Nobuko and Eguchi, Katsumi},
 issue = {3-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {The Interferon (IFN) receptor-mediated signal transduction pathways involve the two novel DNA-binding factors, interferon regulatory factor-1 (IRF-1) and IRF-2. Both recognize the same DNA sequence, in which the expression ratio of IRF-1 to IRF-2 is relevant to induction of IFN-inducible genes, because IRF-1 acts as a transcriptional activator and IRF-2 as a counterpart. In the present study, 54 patients with chronic hepatitis C and the age-and sex-matched 7 subjects with fatty liver as a control were subjected to analysis of the expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue obtained at the time of livert biopsy by reverse transcription-polymerase chain reaction in combination with a restriction fragment length polymorphism assay. The expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue in patients chronically infected by hepatitis C virus (HCV) was significantly higher than that in control, although the values did not correlate with the serum levels of HCV-RNA. Of 54 patients, 28 received IFN treatment, resulting in complete response in 8 patients. With respect to responsiveness to IFN treatment, patients who had complete response had the relatively lower ratios of IRF-1 to IRF-2 mRNA in the liver tissue, compared with those who did not. These results indicate that the IFN-mediated pathway is spontaneously activated in patients with chronic hepatitis C, and that its preceded overactivation counteracts on the efficacy of IFN treatment in these patients., Acta medica Nagasakiensia. 2000, 45(3-4), p.15-19},
 pages = {15--19},
 title = {Attenuation of Responsiveness to Interferon-α  Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus},
 volume = {45},
 year = {2000}
}