{"created":"2023-05-15T16:44:31.356347+00:00","id":20219,"links":{},"metadata":{"_buckets":{"deposit":"44814bad-2d3f-465d-8ec4-c86a3390afa2"},"_deposit":{"created_by":2,"id":"20219","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20219"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020219","sets":["29:30:1713167819629:1398"]},"author_link":["85438","85441","85443","85439","85444","85445","85440","85442","85446","85448","85447"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"19","bibliographicPageStart":"15","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Interferon (IFN) receptor-mediated signal transduction pathways involve the two novel DNA-binding factors, interferon regulatory factor-1 (IRF-1) and IRF-2. Both recognize the same DNA sequence, in which the expression ratio of IRF-1 to IRF-2 is relevant to induction of IFN-inducible genes, because IRF-1 acts as a transcriptional activator and IRF-2 as a counterpart. In the present study, 54 patients with chronic hepatitis C and the age-and sex-matched 7 subjects with fatty liver as a control were subjected to analysis of the expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue obtained at the time of livert biopsy by reverse transcription-polymerase chain reaction in combination with a restriction fragment length polymorphism assay. The expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue in patients chronically infected by hepatitis C virus (HCV) was significantly higher than that in control, although the values did not correlate with the serum levels of HCV-RNA. Of 54 patients, 28 received IFN treatment, resulting in complete response in 8 patients. With respect to responsiveness to IFN treatment, patients who had complete response had the relatively lower ratios of IRF-1 to IRF-2 mRNA in the liver tissue, compared with those who did not. These results indicate that the IFN-mediated pathway is spontaneously activated in patients with chronic hepatitis C, and that its preceded overactivation counteracts on the efficacy of IFN treatment in these patients.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2000, 45(3-4), p.15-19","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00015-P00019"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakata, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morikawa, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inokuchi, Kaoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamasaki, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruta, Shotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatsuhashi, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kusumoto, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Nobuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Katsumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta45_03_03_t.pdf","filesize":[{"value":"557.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta45_03_03_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20219/files/acta45_03_03_t.pdf"},"version_id":"a9c96db7-f3ae-4592-b736-fdeed343c445"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"interferon treatment","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic hepatitis C","subitem_subject_scheme":"Other"},{"subitem_subject":"inter feron regulatory factor-1","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon regulatory factor-2","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatitis C virus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Attenuation of Responsiveness to Interferon-α  Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Attenuation of Responsiveness to Interferon-α  Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus"}]},"item_type_id":"3","owner":"2","path":["1398"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20219","relation_version_is_last":true,"title":["Attenuation of Responsiveness to Interferon-α  Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:03:31.756490+00:00"}