@article{oai:nagasaki-u.repo.nii.ac.jp:00020229,
 author = {Tada, Seiichi and Eishi, Kiyoyuki and Noguchi, Manabu and Hazama, Shirou and Iwamatsu, Miyoko and Taniguchi, Shinichirou},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {We evaluated the ventricular mechanical effects of PhosphodiesteraseIII (PDEIII) inhibitors in the failed heart after global ischemia induced by ventricular fibrillation (VF) using the left ventricular pressure-volume relationship (PVR). In 14 anesthetized open-chest dogs, left ventricular PVR was measured using a conductance catheter. Under administration of milrinone (MIL, n=7) and olprinone (OLP, n=7), the slopes of the LV end-systolic pressure-volume (Emax), arterial end-systolic pressure-stroke volume relations (Ea), ventriculoarterial coupling (Ea/Emax) and preload recruitable stroke work (PRSW) were obtained to evaluate changes in LV performance. The duration of VF was 1 min without cardiopulmonary bypass (CPB). OLP and MIL significantly increased the Emax and PRSW values in the failed heart after VF, and there was no dose-effect relationship at MIL doses of 0.25 to 0.75ﾎｼg/kg/min or at OLP doses of 0.1 to 0.3ﾎｼg/kg/min. The Ea/Emax value after VF was significantly lower in the presence of OLP or MIL than in the absence of these drugs (-45.3% with OLP and -46.5% with MIL). The results indicate that in the heart after transient global ischemia, both OLP and MIL improve hemodynamic and mechanical states in terms of ventriculoarterial coupling., Acta medica Nagasakiensia. 2001, 46(1-2), p.15-20},
 pages = {15--20},
 title = {Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia},
 volume = {46},
 year = {2001}
}