{"created":"2023-05-15T16:44:32.015713+00:00","id":20229,"links":{},"metadata":{"_buckets":{"deposit":"9ddc2371-dbea-4253-bb9e-d2d82fad4b85"},"_deposit":{"created_by":2,"id":"20229","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20229"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020229","sets":["29:30:1713167819629:1399"]},"author_link":["85499","85498","85496","85495","85494","85497"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"20","bibliographicPageStart":"15","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We evaluated the ventricular mechanical effects of PhosphodiesteraseIII (PDEIII) inhibitors in the failed heart after global ischemia induced by ventricular fibrillation (VF) using the left ventricular pressure-volume relationship (PVR). In 14 anesthetized open-chest dogs, left ventricular PVR was measured using a conductance catheter. Under administration of milrinone (MIL, n=7) and olprinone (OLP, n=7), the slopes of the LV end-systolic pressure-volume (Emax), arterial end-systolic pressure-stroke volume relations (Ea), ventriculoarterial coupling (Ea/Emax) and preload recruitable stroke work (PRSW) were obtained to evaluate changes in LV performance. The duration of VF was 1 min without cardiopulmonary bypass (CPB). OLP and MIL significantly increased the Emax and PRSW values in the failed heart after VF, and there was no dose-effect relationship at MIL doses of 0.25 to 0.75ﾎｼg/kg/min or at OLP doses of 0.1 to 0.3ﾎｼg/kg/min. The Ea/Emax value after VF was significantly lower in the presence of OLP or MIL than in the absence of these drugs (-45.3% with OLP and -46.5% with MIL). The results indicate that in the heart after transient global ischemia, both OLP and MIL improve hemodynamic and mechanical states in terms of ventriculoarterial coupling.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2001, 46(1-2), p.15-20","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00015-P00020"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tada, Seiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eishi, Kiyoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noguchi, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hazama, Shirou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamatsu, Miyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniguchi, Shinichirou"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta46_01_03_t.pdf","filesize":[{"value":"668.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta46_01_03_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20229/files/acta46_01_03_t.pdf"},"version_id":"b6a51722-bad3-488f-b242-642d73aa5a8f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phosphodiesterase III inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"End-systolic pressure-volume relationship","subitem_subject_scheme":"Other"},{"subitem_subject":"preload recruitable stroke work","subitem_subject_scheme":"Other"},{"subitem_subject":"ventriculoarterial coupling","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia"}]},"item_type_id":"3","owner":"2","path":["1399"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20229","relation_version_is_last":true,"title":["Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T03:58:04.321846+00:00"}