@article{oai:nagasaki-u.repo.nii.ac.jp:00020230,
 author = {Li, Shengwen and Nomata, Koichiro and Hayashi, Tomayoshi and Aoki, Daiyu and Kanda, Shigeru and Kanetake, Hiroshi},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {High serum levels of carbohydrate antigen19-9 (CA19-9) have been detected in patients with pancreatic cancer and described in several recent case reports of patients with hydronephrosis. However, the mechanism of high serum levels of CA19-9 among hydronephrosis cases remains to be elucidated. In this study, we established a mouse unilateral ureteral obstruction (UUO) model to investigate the expression of CA19-9 protein in renal tissue. To investigate the progression of hydronephrosis following UUO, MR urography and pathological analysis were performed. CA19-9 expression was examined by immunohistochemistry and western blot analysis. MR urography revealed that the grade of pelvic dilatation increased in a time dependent manner. Pathologically, both interstitial cellular infiltration and fibrosis were detected from the second to the fourteenth day after surgery in UUO mice. CA19-9 was detected in the UUO kidney after the second day. The immunoblot analysis revealed that the elevated expression of CA19-9 was demonstrated at an early stage of obstructive nephropathy. Our study shows that the ureteral obstructed kidney is dominated by cell infiltration and induced fibrosis. The selective expression of CA19-9 was detected in renal fibrous tissue. Based on these findings, the level of CA19-9 might be a good indicator for onset of renal fibrosis induced by obstruction., Acta medica Nagasakiensia. 2001, 46(1-2), p.21-25},
 pages = {21--25},
 title = {Upregulation of CA 19-9 in the Mouse Kidney Following Unilateral Ureteral Obstruction},
 volume = {46},
 year = {2001}
}