{"created":"2023-05-15T16:44:32.280310+00:00","id":20233,"links":{},"metadata":{"_buckets":{"deposit":"8f167821-c790-41b3-889b-045c2251b999"},"_deposit":{"created_by":2,"id":"20233","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20233"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020233","sets":["29:30:1713167819629:1399"]},"author_link":["85524","85523","85522","85521","85520"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"47","bibliographicPageStart":"39","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the mechanism of long-term repetitive UVA irradiation in photoaging of the skin, we evaluated albino hairless (SKH: HR1) mice by the irradiation with UVA (300-420nm ) for 12months. The output of irradiated UVA was 30J/cm2/day. Skin samples were taken from each group and examined at 0, 4, 8 and 12months. Morphologically, the structural changes of elastic fibers were observed in the dermis of irradiated group. In immunohistochemistry, tropoelastin, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase (MMP9) were expressed in the fibroblasts in the dermis of photoaged skin. The expressions of tropoelastin, MMP2 and MMP9 mRNA in cultured fibroblasts were analyzed by RT-PCR. The expression of MMP9 mRNA was increased cultured fibroblast derived from irradiated mice. These results suggest that MMP9 is an important mediator in the development of photoaged skin for one-year repetitive exposure to UVA.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2001, 46(1-2), p.39-47","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00039-P00047"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogawa, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jaebae, Sang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamasaki, Youichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta46_01_07_t.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta46_01_07_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20233/files/acta46_01_07_t.pdf"},"version_id":"811ea541-37df-44ab-a1eb-0e154efc174e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"UVA","subitem_subject_scheme":"Other"},{"subitem_subject":"photoaging","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse model","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix metal loproteinase","subitem_subject_scheme":"Other"},{"subitem_subject":"elastin","subitem_subject_scheme":"Other"},{"subitem_subject":"RT-PCR","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation"}]},"item_type_id":"3","owner":"2","path":["1399"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20233","relation_version_is_last":true,"title":["Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T03:58:02.702881+00:00"}