{"created":"2023-05-15T16:44:33.764852+00:00","id":20262,"links":{},"metadata":{"_buckets":{"deposit":"76a3a61a-b01a-4e65-a461-7dc00d470ce4"},"_deposit":{"created_by":2,"id":"20262","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20262"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020262","sets":["29:30:1713167819629:1401"]},"author_link":["85709","85718","85719","85720","85710","85713","85714","85708","85716","85711","85707","85712","85715","85717"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"52","bibliographicPageStart":"47","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Platelet-derived endothelial cell growth factor (PD-ECGF) is one of the angiogenic factors. PD-ECGF expression is elevated in colorectal carcinoma, but its prognostic value does not reach a consensus. The aim of this study is to clarify the prognostic value of the PD-ECGF expression in colorectal carcinomas. PD-ECGF expression was measured by enzyme- linked immunosorbent assay in frozen materials from 71 colorectal cancer patients who had recived curative resection. Patients were divided into high expression and low expression groups based on cut-off value. Correlations among PD-ECGF expression, clinicopathologic features, and disease-free interval were studied by univariate and multivariate analysis. To evaluate the origin of PD-ECGF, serial sections of 71 tumors were stained for PD-ECGF and CD68. PD-ECGF expression in normal mucosa was 34.4 ﾂｱ 15.5 (Units/mg protein) and the cut-off value was 65.4 (mean+2SD). There were no significant correlations between clinicopathological features and PD-ECGF expression. The disease-free interval for high PD-ECGF expression group was significantly longer than that of low expression group (P=0.006). A multivariate Cox's regression analysis revealed a high PD-ECGF expression as an independent factor for better outcome. In immunohistochemical study, almost all tumor cells were negative for PD-ECGF, but stromal macrophages were predominantly positive for PD-ECGF. In conclusion, the PD-ECGF expression measured in this study was derived from stromal macrophages. High PD-ECGF expression was a predictor for favorable outcome after curative resection for colorectal cancer.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2002, 47(1-2), p.47-52","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00047-P00052"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuji, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawai, Terumitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagoe, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haseba, Hirotoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komatsu, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sindou, Hisakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuoka, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Shigekazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibasaki, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nanashima, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasutake, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ayabe, Hiroyoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta47_01_08_t.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta47_01_08_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20262/files/acta47_01_08_t.pdf"},"version_id":"969e1699-bee5-4151-a5ff-dd30a50d18d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"platelet-derived endothelial cell growth factor","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"prognostic factor","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High Level Expression of Platelet-derived Endothelial Cell Growth Factor predicts Good Prognosis in Colorectal Cancer Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High Level Expression of Platelet-derived Endothelial Cell Growth Factor predicts Good Prognosis in Colorectal Cancer Patients"}]},"item_type_id":"3","owner":"2","path":["1401"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20262","relation_version_is_last":true,"title":["High Level Expression of Platelet-derived Endothelial Cell Growth Factor predicts Good Prognosis in Colorectal Cancer Patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:02:30.102881+00:00"}