@article{oai:nagasaki-u.repo.nii.ac.jp:00020265,
 author = {Suga, Kazuo and Yamashita, Naohiro and Chiba, Kenya and Ito, Tetsuya and Kaziwara, Yoshifumi and Yokoyama, Naokata},
 issue = {1-2},
 journal = {Acta medica Nagasakiensia},
 month = {Jun},
 note = {We report a very rare case of multiple endocrine neoplasia type 1 (MEN 1) where a pituitary tumor presenting with acromegaly was associated with a growth hormone-releasing factor (GRF) producing pancreatic tumor. Twenty-seven months after surgery for pituitary adenoma, a 27-year-old male visited our hospital complaining of epigastralgia and back pain. Radiological examination revealed a 7-cm tumor in the pancreatic tail. Endocrinological studies revealed an abnormal increase in the level of growth hormone (GH). After resection of the pancreatic tumor, the GH level was normalized. Immunohistochemical studies confirmed the existence of GRF in the tumor. A diagnosis of GRF-producing pancreatic tumor was established. Nine months after surgery for the pancreatic tumor, the GH level remained normal and the pituitary gland had decreased in size. We speculate that secondary hyperpituitarism was caused by GRF produced by the endocrine pancreatic tumor in this case., Acta medica Nagasakiensia. 2002, 47(1-2), p.61-65},
 pages = {61--65},
 title = {Multiple Endocrine Neoplasia Type 1 Producing Growth Hormone- Releasing Factor in an Endocrine Pancreatic Tumor},
 volume = {47},
 year = {2002}
}