{"created":"2023-05-15T16:44:34.273941+00:00","id":20274,"links":{},"metadata":{"_buckets":{"deposit":"6526f73e-fcd5-4935-b552-0275030a5951"},"_deposit":{"created_by":2,"id":"20274","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20274"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020274","sets":["29:30:1713167819629:1402"]},"author_link":["85784","85785","85778","85781","85782","85780","85779","85777","85783","85776"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"115","bibliographicPageStart":"111","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Activation of poly(ADP-ribose) polymerase-1 (PARP-1) and its subsequent cleavage are early markers of apoptosis. PARP-1 is associated with DNA repair and so chromosome stability, cell cycle regulation, as well as tumorigenesis. To investigate the role of PARP-1 expression in colorectal carcinoma and its metastasis of liver, we compared the expression of PARP-1 in primary colorectal cancers with (n=15) and without liver metastasis (n=17) using a semi-quantitative reverse transcription - polymerase chain reaction. We also examined the expressions of poly(ADP-ribose) (PAR) and p53 in these tumors by immunohistochemistry. A significantly higher PARP-1 mRNA expression was noted in tumors with liver metastasis than those without liver metastasis (p<0.01). Colorectal cancers positively stained for p53 exhibited significantly higher PARP-1 mRNA expression than p53-negative tumors (p<0.01). The PAR labeling index (LI) of tumors with metastasis (0.33 ﾂｱ 0.33) was not significantly different (p=0.35) from that of tumors without liver metastasis (0.38 ﾂｱ 0.19). p53-positive tumors tended to have higher PAR LI levels than p53-negative tumors (p=0.08). Our findings suggest that PARP-1 may contribute to liver metastasis due to its DNA repair activity, resulting in survival of the tumor cells with accumulation of metastaticrelated gene's damages. Detailed analysis of PARP-1 may be useful in cancer research and/or cancer therapy.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2002, 47(3-4), p.111-115","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00111-P00115"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yano, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haseba, Masatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komatsu, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Shigekazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawai, Terumitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasutake, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagoe, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tagawa, Yutaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta47_03_05_t.pdf","filesize":[{"value":"6.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta47_03_05_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20274/files/acta47_03_05_t.pdf"},"version_id":"6dafec3a-b8cd-4a0b-8820-9ea9cedadcdf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"poly(ADP-ribose) polymerase-1","subitem_subject_scheme":"Other"},{"subitem_subject":"poly (ADP-ribose)","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"liver metastasis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated Expression of Poly(ADP-Ribose) Polymerase-1 is Associated with Liver Metastasis in Colorectal Cancer.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated Expression of Poly(ADP-Ribose) Polymerase-1 is Associated with Liver Metastasis in Colorectal Cancer."}]},"item_type_id":"3","owner":"2","path":["1402"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20274","relation_version_is_last":true,"title":["Elevated Expression of Poly(ADP-Ribose) Polymerase-1 is Associated with Liver Metastasis in Colorectal Cancer."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:01:51.938756+00:00"}