{"created":"2023-05-15T16:44:34.570728+00:00","id":20281,"links":{},"metadata":{"_buckets":{"deposit":"6c812304-5232-4fa6-947b-fc11d37666d3"},"_deposit":{"created_by":2,"id":"20281","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20281"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020281","sets":["29:30:1713167819629:1402"]},"author_link":["85830","85829","85831","85832"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"154","bibliographicPageStart":"149","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alcoholic patients have been known to have brain atrophy and cognitive dysfunction. However,recent studies have reported bilateral signal hyperintensities of the globus pallidus on T1-weighted magnetic resonance imaging (MRI) in liver failure, findings that are typically associated with manganese intoxication. The present study compared brain atrophy on T1-weighted MRI, signal intensity ratios of the globus pallidus on T1-weighted MRI, whole blood manganese levels, and Wechsler Adult Intelligence Scale-Revised (WAIS-R) IQ parameters between alcoholics with and without liver cirrhosis, to investigate cognitive dysfunction, MRI findings and manganese levels in alcoholics. Pallidal hyperintensity was visually identified in 80% of alcoholic patients with liver cirrhosis. In addition, a significant correlation was seen between pallidal signal intensity (P.S.I.) ratio and blood manganese level. However, no significant correlations were found between pallidal signal intensity ratio and any of the WAIS-R parameters. These findings suggest that no direct connection exists between cognitive dysfunction and pallidal hyperintensity in alcoholic patients with liver cirrhosis. We confirmed that brain MRI in alcoholics could detect pallidal signal hyperintensity, suggesting severe liver dysfunction. In addition to diagnosis, brain MRI is useful for therapeutic psychoeducation to alcoholic patients with liver cirrhosis, visualizing the severe liver dysfunction.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2002, 47(3-4), p.149-154","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00149-P00154"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Itoh, Tsutomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Katsurou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimanaga, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Yoshibumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta47_03_12_t.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta47_03_12_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20281/files/acta47_03_12_t.pdf"},"version_id":"ba385d16-34f1-44c4-b675-6b62c4e597d2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alcoholism","subitem_subject_scheme":"Other"},{"subitem_subject":"liver cirrhosis","subitem_subject_scheme":"Other"},{"subitem_subject":"magnetic resonance imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"manganese","subitem_subject_scheme":"Other"},{"subitem_subject":"cognitive dysfunction","subitem_subject_scheme":"Other"},{"subitem_subject":"Wechsler Adult Intelligence Scale-Revise d (WAIS-R)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cognitive Dysfunction, MRI Findings and Manganese Levels in Alcoholics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cognitive Dysfunction, MRI Findings and Manganese Levels in Alcoholics"}]},"item_type_id":"3","owner":"2","path":["1402"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20281","relation_version_is_last":true,"title":["Cognitive Dysfunction, MRI Findings and Manganese Levels in Alcoholics"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:01:53.361036+00:00"}