{"created":"2023-05-15T16:44:35.659090+00:00","id":20306,"links":{},"metadata":{"_buckets":{"deposit":"8e7a97bd-de22-4554-974b-29b67198ee20"},"_deposit":{"created_by":2,"id":"20306","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20306"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020306","sets":["29:30:1713167819629:1404"]},"author_link":["85973","85968","85969","85972","85970","85971","85967","85974","85975","85977","85976","85978"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"105","bibliographicPageStart":"101","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: The present study was designed to determine whether the combination of carboplatin (CBDCA) with paclitaxel (PTX) spared CBDCA-induced thrombocytopenia by increased plasma thrombopoietin (TPO) levels. Methods: Patients with non-small-cell and small-cell lung cancer were consecutively assigned to CBDCA with PTX regimen (CBDCA/PTX) and CBDCA with irinotecan (CPT-11) regimen (CBDCA/CPT-11), respectively. Results: Ten patients were entered into either CBDCA/PTX (n=5) or CBDCA/CPT-11 (n=5). CBDCA/PTX showed a lesser reduction of platelet counts than CBDCA/CPT-11 (p<0.05), although more severe neutropenia was observed in CBDCA/PTX (p<0.01). The plasma TPO levels were inversely correlated with circulating platelet counts in CBDCA/PTX and CBDCA/CPT-11. However, the increased rate of plasma TPO levels in CBDCA/PTX was not significantly different from that in CBDCA/CPT-11. Conclusions: These findings suggest that the increased plasma TPO levels in CBDCA/PTX result secondarily from thrombocytopenia, and that circulating TPO is probably not involved in the platelet-sparing effect of PTX.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2003, 48(3-4), p.101-105","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00101-P00105"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kasai, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soda, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oka, Mikio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsurutani, Junji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagashima, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatani, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinoshita, Akitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanda, Tetsuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta48_03_03_t.pdf","filesize":[{"value":"516.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta48_03_03_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20306/files/acta48_03_03_t.pdf"},"version_id":"bb0f5ccf-c662-4f90-b2c8-7e0254eed62a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"thrombopoietin","subitem_subject_scheme":"Other"},{"subitem_subject":"carboplatin","subitem_subject_scheme":"Other"},{"subitem_subject":"paclitaxel","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombocytopenia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plasma Thrombopoietin Levels are Unlikely to Account for the Platelet-sparing Effect of Paclitaxel in Lung Cancer Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma Thrombopoietin Levels are Unlikely to Account for the Platelet-sparing Effect of Paclitaxel in Lung Cancer Patients"}]},"item_type_id":"3","owner":"2","path":["1404"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"20306","relation_version_is_last":true,"title":["Plasma Thrombopoietin Levels are Unlikely to Account for the Platelet-sparing Effect of Paclitaxel in Lung Cancer Patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:01:13.896912+00:00"}