{"created":"2023-05-15T16:30:47.085864+00:00","id":2042,"links":{},"metadata":{"_buckets":{"deposit":"7caba4d4-eea7-4245-ba9f-16baac143dd4"},"_deposit":{"created_by":2,"id":"2042","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2042"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002042","sets":["29:30"]},"author_link":["9364","9368","9355","9365","9369","9356","9363","9360","9361","9367","9359","9354","9362","9358","9366","9357"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"753","bibliographicPageStart":"748","bibliographicVolumeNumber":"96","bibliographic_titles":[{"bibliographic_title":"Acta Dermato Venereologica"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various complement components revealed deposition only of C3 and C5?C9, indicating that no known complement pathways were involved. Studies of in situ hybridization and micro-dissection with quantitative RT-PCR revealed a slight reduction in expression of C3 in patient epidermis. These patients may represent a new disease entity, for which we propose the term “granular C3 dermatosis”. The mechanism for granular C3 deposition in these patients is unknown, but it is possible that the condition is caused by autoantibodies to skin or aberrant C3 expression in epidermal keratinocytes.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta Dermato Venereologica, 96(6), pp.748-753; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Medical Journals/Acta D-V"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2340/00015555-2379","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016 The Authors.This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License."},{"subitem_rights":"c 2016 Acta Dermato-Venereologica."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00015555","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashimoto, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruta, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasukochi, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imanishi, Hisayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekine, Hideharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Teizo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wanibuchi, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gi, Min"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Karpati, Sarolta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sitaru, Cassian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zone, John J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koji, Takehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Norito"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ActaDV96_748.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActaDV96_748.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2042/files/ActaDV96_748.pdf"},"version_id":"7544d4b4-3dc0-4024-a55b-e9359051e855"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Basement membrane zone","subitem_subject_scheme":"Other"},{"subitem_subject":"Bullous disease","subitem_subject_scheme":"Other"},{"subitem_subject":"C3","subitem_subject_scheme":"Other"},{"subitem_subject":"Direct immunofluorescence","subitem_subject_scheme":"Other"},{"subitem_subject":"Granular","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Granular C3 Dermatosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Granular C3 Dermatosis"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-09"},"publish_date":"2017-05-09","publish_status":"0","recid":"2042","relation_version_is_last":true,"title":["Granular C3 Dermatosis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:53:51.788970+00:00"}