{"created":"2023-05-15T16:44:42.003323+00:00","id":20454,"links":{},"metadata":{"_buckets":{"deposit":"70e96a6a-501c-4807-bbff-818d043ceaec"},"_deposit":{"created_by":2,"id":"20454","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20454"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020454","sets":["27:28"]},"author_link":["86501","86497","86499","86500","86498"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"578","bibliographicPageStart":"575","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Journal of Endodontics"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dentin phosphophoryn (DPP) is a dentin sialophosphoprotein gene product that has an RGD motif and repeat sequences of aspartic acid and phosphoserine. To date, the function of DPP in the early stage of reparative dentin formation still remains unclear. The objective of this study was to evaluate the effects of DPP on pulp cell migration and proliferation. DPP promoted cell migration in a concentration-dependent manner, thus increasing it by about 3-fold at 1000 ng/mL compared with the control, but it had no effect on cell proliferation. Dephosphorylated DPP also promoted cell migration, similarly to DPP. However, cell migration was significantly suppressed by the addition of αvβ3 integrin antibody to the medium. Furthermore, porcine DPP-derived RGD peptide, but not its mutant RAD peptide, significantly promoted cell migration. These results indicated that the RGD motif of DPP plays an important role in the migration of human dental pulp cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Endodontics, 34(5), pp.575-578; 2008","subitem_description_type":"Other"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.joen.2008.02.018","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2008 American Association of Endodontists Published by Elsevier Inc."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10614412","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00992399","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasuda, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumikawa, Masanobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Kuniaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukuba, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JouEnd34_575.pdf","filesize":[{"value":"200.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JouEnd34_575.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20454/files/JouEnd34_575.pdf"},"version_id":"a95629f8-794d-46c2-94c0-776cf4c1fd50"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phosphophoryn","subitem_subject_scheme":"Other"},{"subitem_subject":"dentin sialophosphoprotein","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_scheme":"Other"},{"subitem_subject":"RGD motif","subitem_subject_scheme":"Other"},{"subitem_subject":"dental pulp cells","subitem_subject_scheme":"Other"},{"subitem_subject":"reparative dentin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dentin phosphophoryn promotes cellular migration of human dental pulp cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dentin phosphophoryn promotes cellular migration of human dental pulp cells"}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-11"},"publish_date":"2008-04-11","publish_status":"0","recid":"20454","relation_version_is_last":true,"title":["Dentin phosphophoryn promotes cellular migration of human dental pulp cells"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:35:22.536519+00:00"}