{"created":"2023-05-15T16:30:47.260497+00:00","id":2046,"links":{},"metadata":{"_buckets":{"deposit":"2ea2810d-a910-45d3-9bb3-4bd4f5e7161e"},"_deposit":{"created_by":2,"id":"2046","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2046"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002046","sets":["8:9"]},"author_link":["9399","9398","9400"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"245","bibliographicPageStart":"238","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Clinical and Experimental Neuroimmunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lambert?Eaton myasthenic syndrome (LEMS) is an autoimmune disease of the neuromuscular junction and approximately 60% of LEMS patients have a tumor, mostly small cell lung cancer, as a paraneoplastic neurological syndrome. LEMS patients develop a unique set of clinical characteristics, which include proximal muscle weakness, depressed tendon reflexes with post-tetanic potentiation and autonomic symptoms. Interestingly, slightly <10% of LEMS patients have cerebellar ataxia (LEMS with paraneoplastic cerebellar degeneration). Considering its pathomechanism, LEMS is a presynaptic disorder of neuromuscular transmission in which quantal release of acetylcholine is impaired by autoantibodies for P/Q-type voltage-gated calcium channels at active zones, although an animal model by immunizing purified P/Q-type voltage-gated calcium channels has not yet been successful.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Clinical and Experimental Neuroimmunology, 7(3), pp.238-245; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本神経免疫学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cen3.12326","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016 Japanese Society for Neuroimmunology"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17591961","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society for Neuroimmunology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Motomura, Masakatsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakata, Ruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Hirokazu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"CEN7_238.pdf","filesize":[{"value":"609.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CEN7_238.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2046/files/CEN7_238.pdf"},"version_id":"582cb469-edac-4ac1-bcd0-963fc03b499b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lambert?Eaton myasthenic syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"P/Q-type voltage-gated calcium channel","subitem_subject_scheme":"Other"},{"subitem_subject":"paraneoplastic neurological syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"small cell lung cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lambert?Eaton myasthenic syndrome: Clinical review","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lambert?Eaton myasthenic syndrome: Clinical review"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-09"},"publish_date":"2017-05-09","publish_status":"0","recid":"2046","relation_version_is_last":true,"title":["Lambert?Eaton myasthenic syndrome: Clinical review"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:53:44.788563+00:00"}