{"created":"2023-05-15T16:30:47.738281+00:00","id":2057,"links":{},"metadata":{"_buckets":{"deposit":"49212a54-1bc0-4efb-9dc8-92d20b1cd5dc"},"_deposit":{"created_by":2,"id":"2057","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2057"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002057","sets":["8:9"]},"author_link":["9523","9524","9526","9525"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Current Status of Drug-resistant Aspergillus"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"J112","bibliographicPageStart":"J103","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Medical Mycology Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肺アスペルギルス症は死亡率が高く，重要な深在性真菌症である．しかし，抗アスペルギルス活性をもつポリエン系，アゾール系，キャンディン系のなかでも，経口投与が可能な抗真菌薬はアゾール系に限られ，日本では慢性肺アスペルギルス症の外来治療には，イトラコナゾール (ITCZ)，ボリコナゾール (VRCZ) の2種類のアゾール系薬しか使用できない．したがって，アゾール耐性アスペルギルスの出現は臨床的な脅威となる可能性がある．われわれは，日本においてもアゾール耐性のA. fumigatusが臨床現場において存在すること，その耐性機序はアゾール標的分子の変異が原因であること，ITCZ長期投与によりCYP51AのG54変異が誘導され，ITCZ耐性株が産生されることを明らかとした．現在の日本において，複数のアゾールに耐性を示す株は臨床的にも環境においてもまれであり，アスペルギルス症の初期治療において耐性株の存在を考慮する状況ではない．しかし，アゾール耐性株は世界的な拡がりがみられる問題であり，今後も臨床分離株および環境株の継続的調査が必要である．","subitem_description_type":"Abstract"},{"subitem_description":"Aspergillus spp. are important fungi because of the high mortality associated with aspergillosis. However, we have only three classes of anti-aspergillus drugs available; and only two drugs, itraconazole (ITCZ) and voriconazole (VRCZ), are available as oral agents in Japan. If azole-resistant Aspergillus causes chronic aspergillosis, we cannot treat such patients with oral azoles on an outpatient basis. As is the case with foreign countries, we found the existence of azole-resistant Aspergillus fumigatus in clinical settings in Japan. Resistance was attributed to mutations of the target protein (CYP51A). Additionally, we also found that long-term itraconazole treatment induced G54 substitution in CYP51A, causing itraconazole-resistance. Although there are few resistant Aspergillus strains existing in Japan now, we have to continue to find such resistant isolates, which are spreading worldwide.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Medical Mycology Journal, 57(3), pp.J103-J112; 2016","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9525","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tashiro, Masato"}]},{"nameIdentifiers":[{"nameIdentifier":"9526","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Izumikawa, Koichi"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医真菌学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3314/mmj.16.001","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016 日本医真菌学会"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21856486","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2186165X","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society for Medical Mycology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田代, 将人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"泉川, 公一"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MMJ57_J103.pdf","filesize":[{"value":"486.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MMJ57_J103.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2057/files/MMJ57_J103.pdf"},"version_id":"4312e97b-a08b-4c34-9fcf-5b3bf0aa68bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aspergillus fumigatus","subitem_subject_scheme":"Other"},{"subitem_subject":"azole-resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"cyp51","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"薬剤耐性アスペルギルスの現状","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬剤耐性アスペルギルスの現状"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-12"},"publish_date":"2017-05-12","publish_status":"0","recid":"2057","relation_version_is_last":true,"title":["薬剤耐性アスペルギルスの現状"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:53:26.720276+00:00"}