@article{oai:nagasaki-u.repo.nii.ac.jp:00020767,
 author = {Dohtsu, Takesuke and Inokuchi, Tsugio and Hironaka, Ryoji and Ikeda, Hisazumi and Ninomiya, Hidenori and Sekine, Joji},
 issue = {1},
 journal = {Oral medicine & pathology},
 month = {Jun},
 note = {The aim of this study was to assess the healing response to the bone implants treated by heating or freezing. Allogenic calvarial implants treated by heating at 65℃ for 1 hour, 3 freezes of 3 minutes, or boiling for 10 minutes (65℃, frozen and boiled group respectively) were tested for the potential to fill cranial bone defects of rabbits. Both the 65℃ and frozen groups similarly showed more than 60% of new bone formation in terms of the untreated control. Among the three treatment modalities, boiling presented the most remarkable impairment on the reparative capacity of the implants. The autogenous bone segments reimplanted to their original mandibular sites after treatment by heating at 65℃ using microwave or by freezing were revealed to similarly incorporate to the host bone in dog experiments. In summary, heat treatment at 65℃ for 1 hour is comparable with freeze treatment in terms of preservation of the regenerative potential of bone for simultaneous reimplantation., Oral medicine & pathology. 2001, 6(1), p.43-50},
 pages = {43--50},
 title = {Experimental Study on Healing of Bone Implants Treated by Heating or Freezing},
 volume = {6},
 year = {2001}
}