{"created":"2023-05-15T16:45:00.668379+00:00","id":20882,"links":{},"metadata":{"_buckets":{"deposit":"74cee2f2-59cf-4b47-855e-6392e849430c"},"_deposit":{"created_by":2,"id":"20882","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"20882"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00020882","sets":["52:56"]},"author_link":["87986","87987","87988","87983","87985","87984"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supl.","bibliographicPageEnd":"116","bibliographicPageStart":"106","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The relative biological effectiveness (RBE) of ^<252>Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results predominantly from mitotic crossing over induced in wing anlage cells of larvae, while the reverse mutation of eye-color is due to an intragenic structural change (2.96 kb-DNA excision) in the white locus on the X-chromosome. The measurements were performed in a combined mutation assay system so that induced mutant wing-hair clones as well as revertant eye-color clone can be detected simultaneously in the same individual. Larvae were irradiated at the age of 3 days post oviposition with ^<252>Cf neutrons, carbon beam or neon beam. For the neutron irradiation, the RBE values for wing-hair mutations were larger than that for eye-color mutation by about 7 fold. The RBE of carbon ions for producing the wing-hair mutations increased with increase in LET. The estimated RBE values were found to be in the range 2 to 6.5 for the wing-hair. For neon beam irradiation, the RBE values for wing-hair mutations peak near 150 keV/mm and decrease with further increase in LET. On the other hand, the RBE values for the induction of the eye-color mutation are nearly unity in ^<252>Cf neutrons and both ions throughout the LET range irradiated. We discuss the relationships between the initial DNA damage and LET in considering the mechanism of somatic mutation induction.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 1999, 40(Supl.), p.106-116","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshikawa, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuji, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagano, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takada, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hoshi, Masaharu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"jRR40_Supl_106.pdf","filesize":[{"value":"106.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jRR40_Supl_106.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/20882/files/jRR40_Supl_106.pdf"},"version_id":"a5e203e1-4b9c-4fde-9f5b-e80b055a925b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neutron","subitem_subject_scheme":"Other"},{"subitem_subject":"Heavy ion","subitem_subject_scheme":"Other"},{"subitem_subject":"RBE","subitem_subject_scheme":"Other"},{"subitem_subject":"Drosophila","subitem_subject_scheme":"Other"},{"subitem_subject":"Somatic mutation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"RBE-LET Relationships of High-LET Radiations in Drosophila Mutations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RBE-LET Relationships of High-LET Radiations in Drosophila Mutations"}]},"item_type_id":"2","owner":"2","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-30"},"publish_date":"2008-04-30","publish_status":"0","recid":"20882","relation_version_is_last":true,"title":["RBE-LET Relationships of High-LET Radiations in Drosophila Mutations"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:17:06.625621+00:00"}