@article{oai:nagasaki-u.repo.nii.ac.jp:00020934, author = {Kakeya, Hiroshi and Miyazaki, Yoshitsugu and Senda, Hisato and Kobayashi, Tsutomu and Seki, Masafumi and Izumikawa, Koichi and Yanagihara, Kazunori and Yamamoto, Yoshihiro and Tashiro, Takayoshi and Kohno, Shigeru}, issue = {5}, journal = {Antimicrobial Agents and Chemotherapy}, month = {May}, note = {SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg)., Antimicrobial Agents and Chemotherapy, 52(5), p.1868-1870; 2008}, pages = {1868--1870}, title = {Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis}, volume = {52}, year = {2008} }