@article{oai:nagasaki-u.repo.nii.ac.jp:00020935, author = {Hiroshi, Kakeya and Miyazaki, Yoshitsugu and Senda, Hisato and Kobayashi, Tsutomu and Seki, Masafumi and Izumikawa, Koichi and Yamamoto, Yoshihiro and Yanagihara, Kazunori and Tashiro, Takayoshi and Kohno, Shigeru}, issue = {5}, journal = {Antimicrobial Agents and Chemotherapy}, month = {May}, note = {SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes., Antimicrobial Agents and Chemotherapy, 52(5), p.1871-1872; 2008}, pages = {1871--1872}, title = {Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis}, volume = {52}, year = {2008} }