@article{oai:nagasaki-u.repo.nii.ac.jp:00002103,
 author = {Masuda, Marie and Kawakami, Shigeru and Wijagkanalan, Wassana and Suga, Tadaharu and Fuchigami, Yuki and Yamashita, Fumiyoshi and Hashida, Mitsuru},
 issue = {10},
 journal = {Biological & Pharmaceutical Bulletin},
 month = {Oct},
 note = {We previously developed a negatively charged amino acid dendrimer to address the safety concerns associated with the constituent unit of these systems, which resulted in the formation of a sixth-generation glutamic acid-modified dendritic poly(L-lysine) system (KG6E). The aim of this study was to develop a nanocarrier for targeted drug delivery into cancer cells. In this study, we have synthesized a conjugate material consisting of anti-mucin 1 (MUC1) aptamer (anti-MUC1 apt) and KG6E (anti-MUC1 apt/KG6E) for targeted drug delivery to human lung adenocarcinoma A549 cells, which express high levels of the MUC1. The anti-MUC1 apt/KG6E was efficiently internalized by the A549 cells and subsequently transported to the endosomal and lysosomal compartments. In contrast, the cellular association of the sequence scrambled aptamer/KG6E conjugate (scrambled apt/KG6E) was much lower than that of the anti-MUC1 apt/KG6E in A549 cells. These results suggest that our newly developed anti-MUC1 apt/KG6E can be internalized in A549 cells via a MUC1 recognition pathway., Biological & Pharmaceutical Bulletin, 39(10), pp.1734-1738; 2016},
 pages = {1734--1738},
 title = {Anti-MUC1 Aptamer/Negatively Charged Amino Acid Dendrimer Conjugates for Targeted Delivery to Human Lung Adenocarcinoma A549 Cells},
 volume = {39},
 year = {2016}
}