{"created":"2023-05-15T16:30:51.599861+00:00","id":2144,"links":{},"metadata":{"_buckets":{"deposit":"4f70a2fc-f87b-4f1c-b49a-cbcab26c1989"},"_deposit":{"created_by":2,"id":"2144","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2144"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002144","sets":["29:30"]},"author_link":["9943","9933","9935","9932","9942","9937","9940","9938","9941","9934","9939","9936"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"155","bibliographicPageStart":"150","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"EBioMedicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"EBioMedicine, 12, pp.150-155; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ebiom.2016.08.033","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23523964","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takatsuki, Hanae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fuse, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagaki, Takehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mihara, Ban"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takao, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murayama, Shigeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Atarashi, Ryuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Noriyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Katsuya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"EBioMed12_150.pdf","filesize":[{"value":"818.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EBioMed12_150.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2144/files/EBioMed12_150.pdf"},"version_id":"04fff5df-6549-4a04-adf2-1462e9a21d0d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Creutzfeldt-Jakob disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-neural tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion-seeding activity","subitem_subject_scheme":"Other"},{"subitem_subject":"SD50","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-19"},"publish_date":"2017-05-19","publish_status":"0","recid":"2144","relation_version_is_last":true,"title":["Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:52:09.673156+00:00"}