{"created":"2023-05-15T16:30:52.579233+00:00","id":2160,"links":{},"metadata":{"_buckets":{"deposit":"025a7e1f-e3fd-414a-bc46-2d34d1946b61"},"_deposit":{"created_by":2,"id":"2160","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2160"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002160","sets":["35:36"]},"author_link":["10041","10039","10038","10040","10036","10035","10043","10042","10037"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"39","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Tropical Medicine and Health"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The epidemiology of enteric pathogens has not been well studied in Kenya because of wide disparities in health status across the country. Therefore, the present study describes the prevalence of enteropathogenic bacteria, their seasonal variation, and antibiotic resistance profiles among hospitalized diarrheic children in a suburban region of central Kenya. Methods: Fecal samples were collected between July 2009 and December 2013 from a total of 1410 children younger than 5years, hospitalized with acute diarrhea in Kiambu County Hospital, Kenya. Conventional culture, biochemical, and molecular methods were conducted to identify causative bacterial pathogens and their virulence factors. Antimicrobial susceptibility tests were performed using E-test strips and VITEK-2 advanced expert system (AES) to evaluate the drug-resistance pattern of the isolates. Results: Of the 1410 isolates, bacterial infections were identified in 474 cases. Diarrheagenic Escherichia coli (DEC) was the most frequently isolated pathogen (86.5%). Other pathogens such as Aeromonas (5.5%), Shigella (4%), Salmonella (3.4%), Providencia (3.2%), Vibrio spp. (1.1%), Yersinia enterocolitica (1.1%), and Plesiomonas shigelloides (0.2%) were also identified. Mixed bacterial infection was observed among 11.1% of the cases. The highest infection rate was found during the dry season (59.3%, p=0.04). Most of the DEC was found to be multidrug resistant to trimethoprim/sulfamethoxazole 97.6%, amoxicillin 97.6%, erythromycin 96.9%, ampicillin 96.6%, and streptomycin 89%. Conclusions: This study suggests that DEC is the leading diarrhea-causing bacterial pathogen circulating in central Kenya, and seasonality has a significant effect on its transmission. Proper antibiotic prescription and susceptibility testing is important to guide appropriate antimicrobial therapy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Tropical Medicine and Health, 44, 39; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本熱帯医学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s41182-016-0038-1","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c  The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13494147","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society of Tropical Medicine"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shah, Mohammad"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kathiiko, Cyrus"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wada, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Odoyo, Erick"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bundi, Martin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miringu, Gabriel"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Guyo, Sora"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Karama, Mohamed"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichinose, Yoshio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"TMH44_39.pdf","filesize":[{"value":"441.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TMH44_39.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2160/files/TMH44_39.pdf"},"version_id":"f7f575ff-96bb-459f-9a84-a460cc059dac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antimicrobial susceptibility pattern","subitem_subject_scheme":"Other"},{"subitem_subject":"Diarrhea","subitem_subject_scheme":"Other"},{"subitem_subject":"E. coli pathotypes","subitem_subject_scheme":"Other"},{"subitem_subject":"Seasonal variation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prevalence, seasonal variation, and antibiotic resistance pattern of enteric bacterial pathogens among hospitalized diarrheic children in suburban regions of central Kenya","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prevalence, seasonal variation, and antibiotic resistance pattern of enteric bacterial pathogens among hospitalized diarrheic children in suburban regions of central Kenya"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-25"},"publish_date":"2017-05-25","publish_status":"0","recid":"2160","relation_version_is_last":true,"title":["Prevalence, seasonal variation, and antibiotic resistance pattern of enteric bacterial pathogens among hospitalized diarrheic children in suburban regions of central Kenya"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:51:46.468904+00:00"}