{"created":"2023-05-15T16:30:52.709274+00:00","id":2162,"links":{},"metadata":{"_buckets":{"deposit":"04152707-2a00-43f1-9502-6452ffbbe290"},"_deposit":{"created_by":2,"id":"2162","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2162"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002162","sets":["29:30"]},"author_link":["10066","10067","10065","10069","10068","10064"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"280","bibliographicPageStart":"275","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Heme oxygenase 1 (HO-1) is a stress-response protein and its expression is associated with malignant potential and poor prognosis in several types of cancer. The present study investigated the association between HO-1 expression levels and the pathological features, clinical outcomes and other associated factors in patients with non-muscle-invasive bladder cancer (NMIBC). HO-1 expression was evaluated using immunohistochemistry in 147 formalin-fixed tissue specimens. The proliferation index, microvessel density, lymph vessel density and expression of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF)-A, -C, and-D were also investigated. Correlations among variables were analyzed by multivariate analysis. Survival was assessed using Kaplan-Meier survival curves and multivariate statistics. HO-1 expression levels in high-grade and pT1 tumors were significantly higher compared with low-grade and pTa tumors, and were correlated with the proliferation index (P<0.001), lymph vessel density (P=0.021) and COX-2 expression levels (P=0.003). The proliferation index and COX-2 expression levels were also identified as independent contributing factors in multivariate models. Kaplan-Meier survival curves associated HO-1 expression with a poor prognosis in metastasis-free (P=0.047) and cause-specific survival (P=0.017), but not with urinary tract recurrence (P=0.231). Furthermore, HO-1 expression was identified by multivariate analysis to be a significant predictor for cause-specific survival (hazard ratio, 4.08; 95% confidence interval, 1.06-15.66; P=0.004). HO-1 has an important role in the malignant aggressiveness of NMIBC and its expression is associated with cause-specific survival. HO-1-associated activities are regulated by cancer cell proliferation, lymphangiogenesis and COX-2. The results suggest that HO-1 may be a potential therapeutic target and a useful predictive prognostic factor in patients with NMIBC.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oncology Letters, 13(1), pp.275-280; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2016.5416","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016, Spandidos Publications."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuo, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyata, Yasuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsunari, Kensuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Takuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Kojiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Hideki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"OncLet13_275.pdf","filesize":[{"value":"680.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OncLet13_275.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2162/files/OncLet13_275.pdf"},"version_id":"a25aae74-e798-4b22-b170-82806d0e71bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell proliferation","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclooxygenase-2","subitem_subject_scheme":"Other"},{"subitem_subject":"Heme oxygenase 1","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphangiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-muscle-invasive bladder cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular endothelial growth factor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathological significance and prognostic implications of heme oxygenase 1 expression in non?muscle?invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX?2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathological significance and prognostic implications of heme oxygenase 1 expression in non?muscle?invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX?2"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-25"},"publish_date":"2017-05-25","publish_status":"0","recid":"2162","relation_version_is_last":true,"title":["Pathological significance and prognostic implications of heme oxygenase 1 expression in non?muscle?invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX?2"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:51:43.629919+00:00"}