@article{oai:nagasaki-u.repo.nii.ac.jp:00002167,
 author = {Masuda, Shinya and Hisamatsu, Tsubasa and Seko, Daiki and Urata, Yoshishige and Goto, Shinji and Li, Tao-Sheng and Ono, Yusuke},
 issue = {4},
 journal = {Physiological Reports},
 month = {Apr},
 note = {Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of totalbody c-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to c-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice., Physiological Reports, 3(4), e12377; 2015},
 title = {Time‐ and dose‐dependent effects of total‐body ionizing radiation on muscle stem cells},
 volume = {3},
 year = {2015}
}