@article{oai:nagasaki-u.repo.nii.ac.jp:00021682,
 author = {Shimizu, Takeshi and Mieno, Masahiro and Amano, Akio and Iimori, Mitsuaki and Koba, Hisayo},
 issue = {1-4},
 journal = {Acta medica Nagasakiensia},
 month = {Mar},
 note = {The effect of metyrapone on the augmented adrenal 17-hydroxycorticosteroid (17- OHCS) secretion induced by the administration of adrenocorticotrophin (ACTH) was investigated in dogs. A single intravenous injection of ACTH (1 i.u./kg) resulted in the markedly increased secretion of adrenal 17-OHCS; the peak was attained within 60 minutes, and sustained over 3 hours. At the time when the secretion rate caused by ACTH was at a maximum, an intravenous injection of metyrapone (40 mg or 60 mg/kg) produced a rapid and marked decrease in adrenal 17-OHCS secretion. This diminution occurred within 15 minutes and the effect was reversible., Acta medica Nagasakiensia. 1975, 19(1-4), p.13-18},
 pages = {13--18},
 title = {Suppression by Metyrapone of the Adrenal Response to Exogenous Corticotrophin},
 volume = {19},
 year = {1975}
}