@article{oai:nagasaki-u.repo.nii.ac.jp:00021722,
 author = {Mieno, Masahiro and Yamashita, Eriko and Koba, Hisayo and Iimori, Mitsuaki},
 issue = {1-4},
 journal = {Acta medica Nagasakiensia},
 month = {Oct},
 note = {The effects of exogenous luteinizing hormone releasing hormone (LH-RH, 5 μg/kg body wt) on luteinizing hormone (LH) secretion were investigated in anesthetized male dogs pretreated intraventricularly with arginine-vasotocin (AVT, 0.01 μg/kg body wt) 3, 24 or 48 h previously; the rate of secretion of 17-oxosteroids by the testes in vivo served as an index of LH release. The administration of LH-RH into the carotid artery resulted in a notable increase in the secretion of testicular 17-oxosteroids. This effect of LH-RH was diminished by treatment with AVT 3 or 24 h previously but not affected by treatment 48 h earlier. On the other hand, treatment 3 or 24 h previously with AVT did not affect the testicular response to i. v. injection of human chorionic gonadotrophin (HCG, 5 i . u. /kg body wt). It is thus concluded that in the dog, AVT can inhibit the LH releasing effect of LH-RH by acting directly on the anterior pituitary gland even when administered into the third ventricle and the effect is relatively long-lasting., Acta medica Nagasakiensia. 1980, 25(1-4), p.29-34},
 pages = {29--34},
 title = {Arginine-Vasotocin Inhibition of the Canine Pituitary Response to Luteinizing Hormone Releasing Hormone},
 volume = {25},
 year = {1980}
}