@article{oai:nagasaki-u.repo.nii.ac.jp:00021767,
 author = {Kumagai, Kenji},
 issue = {1-3},
 journal = {Acta medica Nagasakiensia},
 month = {Oct},
 note = {The pituitary gland, especially the corticotrophs, of spontaneously hypertensive rats (SHR) at 4 weeks (prehypertensive stage) and 10 weeks of age (early hypertensive stage) was examined immunohistochemically and morphometrically. The corticotrophs (ACTH positive stained cells) were found sparsely in the anterior lobe and a few cells were observed in the area adjacent to the intermediate lobe. The corticotrophs appeared small and stellate in shape and extended their cytoplasm to the neighboring sinusoid. The total area and number of the corticotrophs in SHR was significantly greater than that in WKY at 4 weeks of age. Although the total number of corticotrophs in SHR at 10 weeks was also greater, the total area of these cells was not different from that of WKY. The average width of the zona fasciculata and reticularis in SHR was significantly greater than that of WKY at 4 weeks. These result suggest that there was increased activity of the pituitary-adrenal system in SHR just before their spontaneously developing hypertension., Acta medica Nagasakiensia. 1985, 30(1-3), p.55-67},
 pages = {55--67},
 title = {Pathological Study of the Pituitary-adrenal System in the Spontaneously Hypertensive Rats (SHR) - With Special Reference to the Corticotrophs by Immunohistochemical and Morphometrical Technique-},
 volume = {30},
 year = {1985}
}