@article{oai:nagasaki-u.repo.nii.ac.jp:00021768,
 author = {Nasu, Masaru and Goto, Jun and Goto, Yoichiro and Tashiro, Takayoshi and Itoga, Takashi},
 issue = {1-3},
 journal = {Acta medica Nagasakiensia},
 month = {Oct},
 note = {An experimental model of intracutaneous infection in the guinea pig, which was based on the study of MILES et al. (Br. J. Exp. Path. 38: 79-96, 1957) :and MASKELL (J. Med. Microbiol. 14: 131-140, 1981), was used to investigate the pathogenicity and the effect of chemotherapy with lincomycin, using 36 strains of the genus Bacteroides. The pathogenicity was estimated by intracutaneous injection of 0.1-ml quantities of bacterial suspension into guinea pigs and the value was expressed as the number of inoculated organisms required to induce a skin lesion 10 mm in diameter 24 hours after injection. Bacteroides fragilis was, on average, three times as pathogenic as non-B. fragilis strains (p<0.1). Two intramuscular injections of lincomycin were more effective than a single one against the intracutaneous infection, and the lower was the MIC value, the greater was the effect (p<0.001). This experimental animal model was simple and convenient for estimating the pathogenicity and efficacy of antimicrobial agents. However, the skin lesions were often not clear if the bacteria with low virulence were inoculated and the induced infection is not natural., Acta medica Nagasakiensia. 1985, 30(1-3), p.68-74},
 pages = {68--74},
 title = {Evaluation of an Experimental Animal Model for Estimating the Pathogenicity and the Efficacy of Antibiotic Treatment in Bacterial Infection},
 volume = {30},
 year = {1985}
}