@article{oai:nagasaki-u.repo.nii.ac.jp:00021878, author = {Toda, Takayoshi}, issue = {2-4}, journal = {Acta medica Nagasakiensia}, month = {Dec}, note = {Expression of c-myc oncogene was immunohistochemically examined on aortas of chick embryo of 2-week gestational age, 2-week-old normal cockerels, 4-month-old normal roosters and 4-month-old cholesterl-fed roosters. Chick embryo showed moderate levels of expression of the c-myc oncogene product in the entire wall of the aortas. There was no significant expression of c-myc oncogenic protein in the thickened intima and the tunica media of the ascending aortic arch and its large branches of the cockerels and normal roosters. Cholesterol-fed roosters showed marked expression of c-myc oncogenic protein in the lipid-rich thickened intimal lesions of the ascending aortic arch and its large branches. These results suggest that c-myc oncogene has a role in proliferation and differentiation of aortic medial cells as well as development of atherosclerosis in chickens., Acta medica Nagasakiensia. 1989, 34(2-4), p.173-176}, pages = {173--176}, title = {Immunohistochemical Demonstration of myc Gene Product in Chick Embryo Aorta and Atherosclerotic Lesions in Chickens}, volume = {34}, year = {1989} }