@article{oai:nagasaki-u.repo.nii.ac.jp:00021890,
 author = {Senba, Masachika and Nakamura, Tsuyoshi},
 issue = {2-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {Statistical and histopathological analysis was carried out to determine whether hepatitis B surface antigen with the necropsy diagnosis of hepatitis, cirrhosis, and hepatocellular carcinoma declined during 1964-1984. In this study, the liver specimens from 500 necropsy cases at Nagasaki University Hospital were used, and these materials were stained for hepatitis B surface antigen with immunoperoxidase method. For statistical calculations, we used Cochran's chi-squared test with one degree of freedom for linear trend for proportions. We investigated hepatitis B surface antigen positive rates for the three times periods, 1964-1970, 1971-1977, and 1978-1984, and those in the three diagnosis of hepatitis, cirrhosis, and hepatocellular carcinoma. The decreasing linear trend of hepatitis B surface antigen positivity with time was significant for hepatocellular carcinoma (and also for all three diagnosis combined ). This suggests that infection by hepatitis B virus in blood transfusion had fallen over the period in question., Acta medica Nagasakiensia. 1989, 34(2-4), p.246-249},
 pages = {246--249},
 title = {Long-term Trend of Decreasing Frequency of Hepatitis B Virus Infection in Hepatitis, Cirrhosis, and hepatocellular carcinoma},
 volume = {34},
 year = {1989}
}