@article{oai:nagasaki-u.repo.nii.ac.jp:00021957,
 author = {Taniguchi, Keisuke},
 issue = {1-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {We have studied NK activity against K562 cells and killer activity against NK-resistant Raji cells after administration of Methotrexate. Vinblastine, Adriamycine and Cis-platin (M-VAC) in patients with transitional cell carcinoma and found the appearance of strong lytic activity against K562 cells and Raji cells (lymphokine activated killer(LAK)-like activity) appeared 24.3 ± 6.5 days after the administration of first cycle of M-VAC and the lytic unit (LU) was 418.4 ± 177.4 (LU of pre-chemotherapy: 88.6 ± 61.2). NK activity against K562 cells showed the same course as lymphokinne activated killer-like activity. There was a significant difference in activity of NK cells and LAK-like cells between pre-chemotherapy and maximum. NK cells and LAK-like cells activities after second or third cycle of M-VAC showed the same course as those of first cycle of M-CAC. Lymphocyte count decreased temporarily and increased during maximal activities of NK cells and LAK-like cells in each cycle of M-VAC therapy. However, maximal peak of lymphocyte count delayed in comparison with that of maximal activities of NK cells and LAK-like cells. Lymphokines, such as IL-2 may play a role to generate these enhanced NK activity and LAK-like activity. The data presented in this report suggests that the nature, dose, and timing of chemotherapeutic agent should be considered from the point of immunological mechanism., Acta medica Nagasakiensia. 1991, 36(1-4), p.29-33},
 pages = {29--33},
 title = {Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)},
 volume = {36},
 year = {1991}
}