{"created":"2023-05-15T16:45:47.165095+00:00","id":21957,"links":{},"metadata":{"_buckets":{"deposit":"216634c9-af84-4639-87f0-49f2bd2e0499"},"_deposit":{"created_by":2,"id":"21957","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"21957"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00021957","sets":["29:30:1713167819629:1562"]},"author_link":["93689"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"33","bibliographicPageStart":"29","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have studied NK activity against K562 cells and killer activity against NK-resistant Raji cells after administration of Methotrexate. Vinblastine, Adriamycine and Cis-platin (M-VAC) in patients with transitional cell carcinoma and found the appearance of strong lytic activity against K562 cells and Raji cells (lymphokine activated killer(LAK)-like activity) appeared 24.3 ± 6.5 days after the administration of first cycle of M-VAC and the lytic unit (LU) was 418.4 ± 177.4 (LU of pre-chemotherapy: 88.6 ± 61.2). NK activity against K562 cells showed the same course as lymphokinne activated killer-like activity. There was a significant difference in activity of NK cells and LAK-like cells between pre-chemotherapy and maximum. NK cells and LAK-like cells activities after second or third cycle of M-VAC showed the same course as those of first cycle of M-CAC. Lymphocyte count decreased temporarily and increased during maximal activities of NK cells and LAK-like cells in each cycle of M-VAC therapy. However, maximal peak of lymphocyte count delayed in comparison with that of maximal activities of NK cells and LAK-like cells. Lymphokines, such as IL-2 may play a role to generate these enhanced NK activity and LAK-like activity. The data presented in this report suggests that the nature, dose, and timing of chemotherapeutic agent should be considered from the point of immunological mechanism.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1991, 36(1-4), p.29-33","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00029-P00033"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taniguchi, Keisuke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta36_01_07_t.pdf","filesize":[{"value":"359.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta36_01_07_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/21957/files/acta36_01_07_t.pdf"},"version_id":"8ea8f9b7-a000-45d1-ace4-bd41ac328535"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)"}]},"item_type_id":"3","owner":"2","path":["1562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"21957","relation_version_is_last":true,"title":["Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:09:14.585519+00:00"}