@article{oai:nagasaki-u.repo.nii.ac.jp:00021974,
 author = {Mine, Yoshikazu},
 issue = {1-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {To investigate the effect of OK-432 and 1-arginine HC1 on the artificial metastases in lung, mice were injected mouse colon carcinoma, colon 26 cells(1×10 6). Pulmonary nodules produced by the i. v. injection of 1×10 6 colon tumor 26 cells into a caudal vein were evaluated after 3 weeks. OK-432, 1KE/mouse, was administered by the i. v. injection three times on day 0, 2, 4 after the tumor injection. L-arginine HC1, 50mg/mouse, was given by the i. p. injection 6-7 times on day 0, 1, 2,3,4,5,6. IV administration of OK-432 led to a significant suppression of lung metastases formation in comparison to salin-injected animals. Furthermore, OK-432 and i. p. administration of 1-arginine HC1 let to a considerable, synergisticaly retardation of tumor metastasis. The suppressive effect of OK-432 and 1-arginine HC1 on the artificial lung metastases may be due to its activation of the immunologic system. And this work suggest that OK-432 and 1-arginine HC1 enhanced the phagocytic activity of macrophages in vivo., Acta medica Nagasakiensia. 1991, 36(1-4), p.128-135},
 pages = {128--135},
 title = {Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice},
 volume = {36},
 year = {1991}
}