{"created":"2023-05-15T16:45:48.271693+00:00","id":21974,"links":{},"metadata":{"_buckets":{"deposit":"3a610db6-683d-4224-a23f-f00294ecec6e"},"_deposit":{"created_by":2,"id":"21974","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"21974"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00021974","sets":["29:30:1713167819629:1562"]},"author_link":["93765"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"135","bibliographicPageStart":"128","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To investigate the effect of OK-432 and 1-arginine HC1 on the artificial metastases in lung, mice were injected mouse colon carcinoma, colon 26 cells(1×10 6). Pulmonary nodules produced by the i. v. injection of 1×10 6 colon tumor 26 cells into a caudal vein were evaluated after 3 weeks. OK-432, 1KE/mouse, was administered by the i. v. injection three times on day 0, 2, 4 after the tumor injection. L-arginine HC1, 50mg/mouse, was given by the i. p. injection 6-7 times on day 0, 1, 2,3,4,5,6. IV administration of OK-432 led to a significant suppression of lung metastases formation in comparison to salin-injected animals. Furthermore, OK-432 and i. p. administration of 1-arginine HC1 let to a considerable, synergisticaly retardation of tumor metastasis. The suppressive effect of OK-432 and 1-arginine HC1 on the artificial lung metastases may be due to its activation of the immunologic system. And this work suggest that OK-432 and 1-arginine HC1 enhanced the phagocytic activity of macrophages in vivo.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1991, 36(1-4), p.128-135","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00128-P00135"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mine, Yoshikazu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta36_01_24_t.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta36_01_24_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/21974/files/acta36_01_24_t.pdf"},"version_id":"1c4b9b6a-f24b-4673-b25a-91ff66bdc1bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice"}]},"item_type_id":"3","owner":"2","path":["1562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"21974","relation_version_is_last":true,"title":["Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:09:18.893750+00:00"}