{"created":"2023-05-15T16:45:50.587983+00:00","id":22006,"links":{},"metadata":{"_buckets":{"deposit":"ffda9474-7a5c-4af3-81e5-a12463fa17f3"},"_deposit":{"created_by":2,"id":"22006","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"22006"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00022006","sets":["29:30:1713167819629:1563"]},"author_link":["93924"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"78","bibliographicPageStart":"74","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase-∂  that is synthesized during the late G1 phase through the S phase of cell proliferation. The expression of PCNA correlates strongly with cell proliferation. In the present study, employing NC-012, which is an anti-human PCNA monoclonal antibody, we performed immunohistochemical staining on specimens obtained from 71 new prostatic carcinoma patients by needle biopsy. We analyzed the results of PCNA immunoreactivity for correlation with the prognosis of the patients. The positive staining rate was 0~11.4% for prostatic carcinoma, while it was 0~2.6% in 10 cases of benign prostatic hypertrophy. The PCNA-positive rate tended to be high in cases of moderately to poorly differentiated prostatic carcinoma, but it was not significant. With regard to the prognosis, it was found that the prognosis tended to be worse in the PCNA- positive cases compared with the PCNA-negative cases. Further, multivariate survival analysis of six parameters (i. e., the patient's age, histological grade, clinical stage, serum prostatic acid phosphatase, initial treatment and the PCNA-positive rate) revealed that the clinical stage, histological grade and the PCNA-positive rate were the first, second and third most significant prognostic parameters, respectively.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1993, 38(2-4), p.74-78","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00074-P00078"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiraishi, Kazutaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta38_02_08_t.pdf","filesize":[{"value":"709.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta38_02_08_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/22006/files/acta38_02_08_t.pdf"},"version_id":"9ed4cb0a-e156-48c1-b8f3-efc9b33c9ed2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Proliferating Cell Nuclear Antigen (PCNA) in Prostatic Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Proliferating Cell Nuclear Antigen (PCNA) in Prostatic Carcinoma"}]},"item_type_id":"3","owner":"2","path":["1563"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"22006","relation_version_is_last":true,"title":["Proliferating Cell Nuclear Antigen (PCNA) in Prostatic Carcinoma"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:07:54.725608+00:00"}