@article{oai:nagasaki-u.repo.nii.ac.jp:00022011,
 author = {Kinoshita, Noboru},
 issue = {2-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {Hepatic expression of hepatitis B core antigen(HBcAg)and β2- mi croglobulin (β2-MG) was studied in 42 patients with liver biopsy-proven chronic hepatitis B; 31 were hepatitis Be antigen (HBeAg)-seropositive and 11 were anti-HBeAg antibody (anti- HBe)-seropositive at base line. The degrees of expression of both HBcAg and β2-MG at base line were significantly higher in HBeAgseropositive patients than in anti-HBe-seropositive patients (p < 0.001 and p < 0.001, respectively). During two-year-follow-up, 14 of 31 HBeAg-seropositive patients were seroconverted to anti-HBe (HBe-seroconversion). When the base line hepatic expression of HBcAg and β2-MG was compared between the patients with subsequent HBe-seroconversion and the non-soroconverted patients, β2-MG expression on hepatocytes in the patients with subsequent HBe-seroconversion was significantly more intense than that in the non-soroconverted patients (p < 0.025). In contrast, the degrees of HBcAg expression at base line were not different between the two groups. These results suggest that the hepatic expression of β2-MG as well as that of HBcAg correlates with the serum level of HBeAg and that the increased expression of β2-MG is followed by HBe-seroconversion in patients with chronic hepatitis B., Acta medica Nagasakiensia. 1993, 38(2-4), p.95-99},
 pages = {95--99},
 title = {Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B},
 volume = {38},
 year = {1993}
}