{"created":"2023-05-15T16:45:50.911752+00:00","id":22011,"links":{},"metadata":{"_buckets":{"deposit":"f6599d11-1dce-4642-846a-d8eb07bf7f65"},"_deposit":{"created_by":2,"id":"22011","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"22011"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00022011","sets":["29:30:1713167819629:1563"]},"author_link":["93951"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"99","bibliographicPageStart":"95","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatic expression of hepatitis B core antigen(HBcAg)and β2- mi croglobulin (β2-MG) was studied in 42 patients with liver biopsy-proven chronic hepatitis B; 31 were hepatitis Be antigen (HBeAg)-seropositive and 11 were anti-HBeAg antibody (anti- HBe)-seropositive at base line. The degrees of expression of both HBcAg and β2-MG at base line were significantly higher in HBeAgseropositive patients than in anti-HBe-seropositive patients (p < 0.001 and p < 0.001, respectively). During two-year-follow-up, 14 of 31 HBeAg-seropositive patients were seroconverted to anti-HBe (HBe-seroconversion). When the base line hepatic expression of HBcAg and β2-MG was compared between the patients with subsequent HBe-seroconversion and the non-soroconverted patients, β2-MG expression on hepatocytes in the patients with subsequent HBe-seroconversion was significantly more intense than that in the non-soroconverted patients (p < 0.025). In contrast, the degrees of HBcAg expression at base line were not different between the two groups. These results suggest that the hepatic expression of β2-MG as well as that of HBcAg correlates with the serum level of HBeAg and that the increased expression of β2-MG is followed by HBe-seroconversion in patients with chronic hepatitis B.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1993, 38(2-4), p.95-99","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00095-P00099"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinoshita, Noboru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta38_02_13_t.pdf","filesize":[{"value":"12.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta38_02_13_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/22011/files/acta38_02_13_t.pdf"},"version_id":"00738aff-601d-4fb8-99bf-78d10c700964"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"croglobulin","subitem_subject_scheme":"Other"},{"subitem_subject":"HBcAg","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic hepatitisB","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B"}]},"item_type_id":"3","owner":"2","path":["1563"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"22011","relation_version_is_last":true,"title":["Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:07:55.710622+00:00"}