@article{oai:nagasaki-u.repo.nii.ac.jp:00022034,
 author = {Senba, Masachika and Zhong, Xue-Yun and Itakura, Hideyo},
 issue = {2-4},
 journal = {Acta medica Nagasakiensia},
 month = {Dec},
 note = {Proliferative activity of nasopharyngeal carcinoma (NPC) using 20 biopsy cases obtained from southern China were analyzed by immunolabelling with the monoclonal antibody of proliferating cell nuclear antigen (PCNA), the numbers of interphase silver stained nucleolar organizer regions (AgNORs), and mitotic indices. Nucleolar organizer regions (NORs) are loops of ribosomal DNA (rDNA) occurring in the nucleoli of cells, which transcribe to ribosomal RNA (rRNA) and ultimately direct ribosome and protein formation. PCNA is a nuclear protein synthesized in the nucleus late in G1 phase, peaking during S phase and subsiding during G2 and M phases of the cell cycle. These may indicate that PCNA and AgNORs are present at different stages of the cell cycle. The authors found that 28% of differentiated non-keratinizing carcinoma type of NPC and 18% of undifferentiated carcinoma type of NPC were positively stained by PCNA. The mean AgNOR counts for differentiated non-keratinizing carcinoma type of NPC, and undifferentiated carcinoma type of NPC were 1.8 and 1.2, respectively. The mean mitotic counts for differentiated non-keratinizing carcinoma type of NPC and undifferentiated carcinoma type of NPC were 3.4 and 2.1, respectively. Therefore, it is suggested that PCNA labelling immunoreactivity may be correlated with AgNORs score and mitotic indeces, thus in NPC, these number and size have been regarded as markers of cell proliferative ability., Acta medica Nagasakiensia. 1993, 38(2-4), p.200-205},
 pages = {200--205},
 title = {Proliferating Cell Nuclear Antigen (PCNA), Nucleolar Organizer Regions (AgNORs), and Mitotic Indeces in Nasopharyngeal Carcinoma},
 volume = {38},
 year = {1993}
}