{"created":"2023-05-15T16:45:54.281467+00:00","id":22063,"links":{},"metadata":{"_buckets":{"deposit":"899b8d57-169e-4216-89a0-ac709eafe501"},"_deposit":{"created_by":2,"id":"22063","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"22063"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00022063","sets":["29:30:1713167819629:1386"]},"author_link":["94254"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"38","bibliographicPageStart":"34","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Treatment with interferon (IFN) for renal cell carcinoma was started in 1982 as one of the immunotherapies, but it is not so effective and no definite way of administration has been established yet. In thie report for the purpose of studying  the action mechanism of IFN-α and IFN-γ, cytotoxic activity of peripheral blood mononuclear cells (PBMNCs) of the patients with renal cell carcinoma. When the patients' PBMNCs were treated with IFNs at various concentrations, difference was noted in each patient referring to IFNs and their concentrations for obtaining the maximum LAK-like activity using ACHN derived from human renal cell carcinoma as target cells. Further, the combined effect of cytotoxicity obtained by IFN-α and IFN- γ at their optimal concentration was additive in comparison with LAK-like activities upon therapy with IFN-α or IFN- γ alone respectivly. Further, when the action mechanism of IFN-γ was studied referring to subpopulation of the normal donor'PBMNCs by cell sorting, the strong LAK-like activity was induced on the lymphocyte fraction CD3(+)CD4(-). Further in consideration of cytokine concentrations measured  and the above results, it seems that IFN-γ acts directly on the lymphocyte fraction CD3(+) CD4(-) to induce the LAK-like activity.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 1994, 39(1-3), p.34-38","subitem_description_type":"Other"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00034-P00038"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakaguchi, Miki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta39_01_07_t.pdf","filesize":[{"value":"541.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta39_01_07_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/22063/files/acta39_01_07_t.pdf"},"version_id":"ab783b21-1ef5-42fb-b63e-926f2e46fa35"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma"}]},"item_type_id":"3","owner":"2","path":["1386"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-13"},"publish_date":"2008-03-13","publish_status":"0","recid":"22063","relation_version_is_last":true,"title":["In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:07:13.818205+00:00"}