{"created":"2023-05-15T16:46:17.527084+00:00","id":22529,"links":{},"metadata":{"_buckets":{"deposit":"96d00d4c-1d02-444e-badf-d2f11813859c"},"_deposit":{"created_by":2,"id":"22529","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"22529"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00022529","sets":["29:30:1713167819629:1605"]},"author_link":["95834"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Type 1 diabetes of both the human and NOD mouse is associated with autoimmunity directed against insulin which is the only β cell specific autoantigen. Variable number of tandem repeats in the 5′ region of insulin gene on chromosome 11 is associated with the risk of type 1 diabetes in human. Mice have two insulin genes including the insulin 1 gene (chromsome 19) and the insulin 2 gene (chromsome 7). The insulin 2 gene knockout when bred onto NOD mice accelerates diabetes. In contrast to insulin 2, diabetes and insulitis were markedly reduced in insulin 1 knockout mice with decreased and delayed diabetes. Autoantibodies to insulin can predict diabetes in man and NOD mice. Insulin peptides can be used to induce insulitis and diabetes in non-diabetic strain mice. Our results suggest that insulin molecule is a possible \"primary\" autoantigen that initiates a pathogenesis of type 1 diabetes. An administration of insulin or its peptide can prevent the development of diabetes in NOD mice but we cannot at present safely prevent type 1 diabetes in humans. A series of clinical trials are under way and planned.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2004, 49(1-2), p.1-6","subitem_description_type":"Other"}]},"item_3_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/49.1"}]}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00001-P00006"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{"nameIdentifier":"95834","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"acta49_01_01.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta49_01_01.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/22529/files/acta49_01_01.pdf"},"version_id":"50a80b4f-afe4-4d40-bafa-30b0e744c1d3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Type1diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"NODmouse","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulingene","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulinautoantibody","subitem_subject_scheme":"Other"},{"subitem_subject":"InsulinBchainpeptide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Insulin as the \"Primary\" Autoantigen in Type 1 Diabetes?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Insulin as the \"Primary\" Autoantigen in Type 1 Diabetes?"}]},"item_type_id":"3","owner":"2","path":["1605"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-02"},"publish_date":"2007-11-02","publish_status":"0","recid":"22529","relation_version_is_last":true,"title":["Insulin as the \"Primary\" Autoantigen in Type 1 Diabetes?"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:00:57.583757+00:00"}