{"created":"2023-05-15T16:46:20.430515+00:00","id":22597,"links":{},"metadata":{"_buckets":{"deposit":"e513d4b4-b5ad-44ef-987f-e0146f5677bf"},"_deposit":{"created_by":2,"id":"22597","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"22597"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00022597","sets":["29:30:1713167819629:1610"]},"author_link":["96134","96133","96130","96131","96132"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"29","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Treatment of pulmonary hypertension has not yet been established and effective drug therapies are required. We hypothesized that inhibition of cyclic guanosine monophoshate (cGMP)- phosphodiesterase (PDE) would result in specific vasodilation of the hypertensive pulmonary arteries. This study was carried out to determine whether PDE V inhibitors could dilate pulmonary artery (PA) from monocrotaline-induced pulmonary hypertensive rats. Thirty-six Wistar rats were given either monocrotaline (105 mg/kg) or normal saline (control) subcutaneously. Three weeks later, the PA rings were isolated and mounted in 5-mL organ chambers. After precontraction with norepinephrine (0.1 μmM), one of two PDE V inhibitors, zaprinast and dipyridamole, was added in a cumulative fashion. We also investigated whether nitric oxide synthetase (NOS) inhibitor modifies the effects of the PDE V inhibitors on the PA. Zaprinast and dipyridamole dose-dependently dilated the PA from either saline- or monocrotaline- treated rats. There was no difference in the dilatory effect between monocrotaline and saline rats. Pretreatment of a NOS inhibitor (NG-nitro-L-arginine methyl ester (0.1 mM)) reduced moderately the vasodilatory effect of zaprinast on the PA from monocrotaline-treated but not saline-treated rats. The results suggest that PDE V inhibitors exert a strong vasodilating effect on PA of pulmonary hypertensive rats as well as on that of normal rats, and that NO plays a role, at least in part, in the effect of PDE V inhibition on PA of pulmonary hypertensive rats.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia. 2005, 50(1), p.29-33","subitem_description_type":"Other"}]},"item_3_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.29"}]}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00029-P00033"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makita, Tetsuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsutsumi, Yohsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cho, Sungsam"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumikawa, Koji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"acta50_01_29.pdf","filesize":[{"value":"191.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta50_01_29.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/22597/files/acta50_01_29.pdf"},"version_id":"41e05e78-95fa-48ed-a1a4-f215adb0e545"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PDEVinhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"Monocrotaline","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_scheme":"Other"},{"subitem_subject":"Pulmonaryhypertension","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats"}]},"item_type_id":"3","owner":"2","path":["1610"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-02"},"publish_date":"2007-11-02","publish_status":"0","recid":"22597","relation_version_is_last":true,"title":["Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-17T04:00:13.473649+00:00"}