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Secondary In Vitro Sensitization of T Cells with Respect to Adoptive Immunotherapy for Cancer: Spread and Clonal Proliferation of Lymphocytes of Different T-Cell Subsets
http://hdl.handle.net/10069/9365
http://hdl.handle.net/10069/9365f3ff6cc8-94e6-4523-8405-a7bbb3652312
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta51_03_79.pdf (664.3 kB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||||
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| 公開日 | 2007-11-02 | |||||||
| タイトル | ||||||||
| タイトル | Secondary In Vitro Sensitization of T Cells with Respect to Adoptive Immunotherapy for Cancer: Spread and Clonal Proliferation of Lymphocytes of Different T-Cell Subsets | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Secondaryinvitrosensitization | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Cancerextract | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Inhibitoryfactor | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | RegulatoryTcells | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Paracorticalactivity | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 著者 |
Raichev, Ivan
× Raichev, Ivan
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | For the aim of adoptive immunotherapy in mice bearing transplanted sarcoma and in cancer patients, we performed secondary in vitro sensitization to obtain functionally active T cells. Specific tumor antigens, cytokines, viable irradiated tumor cells, an anti-CD3 monoclonal antibody and others were used. We preferred the method of complex stimulation with PHA, T-cell growth factor or IL-2, in small doses, and 3 M KCl tumor extract. In patients with cancer, many authors reported for an activity of cells with suppressor function. CD4+CD25+ regulatory T cells increased in number in peripheral blood and lymph node lymphocytes, and among tumor-infiltrating cells. In our investigations, production both of factor, inhibiting Ehrlich-cell migration and suppressor factor was revealed from T cells, in vitro sensitized with 3 M KCl cancer extract containing solubilized cancer antigens. The suppressor factor decreased or abrogated the effect of the inhibitory Ehrlich-cell migration factor. It is important to further scrutinize the spread and clonal proliferation of in vitro sensitized, transferred T cells, thus, their subsequent invasion in cancer node, in the host. | |||||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 51, 号 3, p. 79-87, 発行日 2006-09 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 00016055 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00508430 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関係URI | ||||||||
| 関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/51.79 | |||||||
| sortkey | ||||||||
| 値 | P00079-P00087 | |||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Acta medica Nagasakiensia. 2006, 51(3), p.79-87 | |||||||
